Current Issue : April - June Volume : 2015 Issue Number : 2 Articles : 5 Articles
The present study was designed to investigate the effect of Allium sativum (Liliaceae) bulb extract on early stage diabetic cardiomyopathy in alloxan-induced diabetic rats. Diabetes was induced in wistar rats by injecting single dose administration of alloxan (150 mg/kg, i.p.). In the present study 35 rats were divided into 7 groups, each group containing 5 rats; non-diabetic group, diabetic group and A. sativum extract treated group. Each extract was administered orally at the dose of 100 mg/kg to the diabetic rats daily for 14 days. Fasting blood glucose (FBG), total cholesterol (TC), creatine kinase (CK) and lactate dehydrogenase (LDH) were determined by standard methods. Administration of different A. sativum extracts i.e. ethanol (EASE), chloroform (CASE), aceton (AASE) and aqueous (AqASE) were found to decrease the level of FBG, TC, CK and LDH as compared to diabetic control group. AqASE was found to decrease the LDH and CK level more significantly as compared to other extracts. Histopathological studies revealed salvage in the morphological dearrangements as indicated by decrease in necrotic lesions, perivascular oedema and inflammatory cells in A. sativum extracts treated group as compared to diabetic control. The present study conclude that administration of AqASE attenuate the severity and improves the myocardium functioning in alloxan induced DCM more significantly as compared to other extracts....
The present investigation was designed to appraise the ameliorative effect of ethanolic extract (HPEE) and aqueous extract (HPAE) of bark of H. pubescens on alloxan induced diabetic rats. The oral administration of ethanolic and aqueous extracts at dose of 250 and 500 mg/kg b.w. was given to alloxan (150 mg/kg b.w) induced diabetic rats for a period of 14 days. Glibenclamide (10 mg/kg b.w) was the reference drug used in the treatment. Blood glucose level was measured on 3rd and 14th day of the treatment using commercial kit. Blood samples were collected and centrifuged to separate serum for estimation of lipid profile and other biochemical parameters. Daily oral administration of H. pubescens bark extracts (250 and 500 mg/kg) and glibenclamide (10 mg/kg) significantly (p<0.001) reduced fasting blood glucose and normalized the lipid profile in comparison to diabetic control group which might be due to the presence of alkaloids, sterols and tannins that have been found to be beneficial in controlling diabetes and many other diseases. Additionally, both cardiac enzymes CKMB as well as LDH were significantly reduced in both H. pubescens and glibenclamide treated diabetic rats compared to the non-treated group indicating better control of blood sugar level. The effect of alcoholic extract 500 mg/kg was nearly equal to that of reference drug glibenclamide in most of the observation. Hence, it can be concluded that HPEE possess antihyperglycemic activity with antihyperlipidemic activity which may prove beneficial in cardiovascular complications associated with diabetes mellitus....
An important aspect of the gerontology research is the identification and analysis of compound that delay aging and extend lifespan; these studies can test theories of aging, lead to discovery of endogenous systems that influence aging and establish the foundation for the treatments that might delay normal human aging. This research article focuses on the various treatments/experiments with the plant adaptogen. Extracts from plant adaptogens such as Withania somnifera (Ashvagandha) have been shown to increase the resistance of a variety of organisms against the damaging effect of different stress conditions. We observed that Ashvagandha extracts also increase the mean lifespan of the nematode Caenorhabditis elegans in a dose-dependent way. Through three independent experiments we found that, 1 mg/ml Withania somnifera significantly increased life span between 28.57% (P<0.0001), increased the maximum lifespan with 3.5-4 days. With higher concentrations, toxic effect was observed, whereas at the highest concentrations tested (2500 µg/ml Withania somnifera) a lifespan shortening effect was observed by 15–25% (P<0.0001). Based on the observation of the present study, it was suggested that adaptogens were practiced as anti-stress agent their optimize concentration increased stress resistance and increase the lifespan of nematode....
Smithia sensitiva belonging to the family Fabaceae is a plant used as an anti inflammatory and anti-oxidant drug by tribal peoples in kerala. The isolation and characterization of phytoconstituents will help to evaluate which type of active constituent may be responsible for potent pharmacological activity. Therefore in the present study, initiatives were taken to explore different extracts of the plant for isolating active constituents and to characterize the isolated compounds so that it will be helpful to determine which type of active constituent may be responsible for making it a potent anti-inflammatory plant. The inhibitory effect of compounds isolated from MESS on in-vitro enzymatic activities were measured against COX 1 and COX 2. In this study the compound III at a concentration of 50 µg/ml displayed more COX 2 inhibition. Compounds III from methanoloic extract of Smithia sensitiva (MESS) showed maximum % inhibition (80.59). It can be concluded that the activity related to MESS mainly due to the presence of flavonoids and triterpenoids....
The health beneficial effects of an Asparagus racemosus root, although many in-vitro studies revealed a striking variety of biochemical and pharmacological properties data about the beneficial effects of A. racemosus root in whole organisms, especially with respect to ageing, are quite limited. We used the well established model organism C. elegans to elucidate the protective effects of A. racemosus root extract. Significant characteristic for the gerontology research is recognition and study of compound that delay aging and extend lifespan. These studies can set up the base for the treatments that might delay normal human aging and gave protection against different stress condition. This research article focuses on the dose dependent treatments of C. elegans with the A. racemosus root extract. Extracts have been shown to increase the resistance of organisms against the damaging effect of different stress conditions. We observe that A. racemosus extracts also boost the mean lifespan of the nematode C. elegans in a dose-dependent way. Through three independent experiments we found that, 1 mg/ml A. racemosus significantly increased life span 30.93% (P<0.0001), increased the maximum lifespan with 4-4.5 days in lifespan assay and in different stress condition increased life span 13-20% (P<0.0001). With higher concentrations, toxic effect was observed, whereas at the highest concentrations tested (2500 µg/ml A. racemosus) a lifespan shortening effect was observed of 5%. Based on the observation of present study, it was suggested that A. racemosus are proficient as anti-stress agent their optimize concentration increased stress resistance and increase the lifespan of nematode....
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